TEAM

Cellular interactions, neurodegeneration and neuroplasticity

Group leader : L. Kerkerian – Le Goff

Our team aims at better understanding the mechanisms of cellular interactions, neurodegeneration and neuroplasticity in the context of Parkinson’s disease.

FOR BEGINNERS

Neurodegeneration designs the progressive pathological mechanisms leading to death of nerve cells. Many neurodegenerative disorders, including Parkinson’s disease, occur as a result of neurodegenerative processes whose causes are not fully elucidated. Understanding those mechanisms is essential for the development of preventive or curative treatments.

This picture from Lydia's lab studying neuroplasticity shows the adult neurogenesis n the hippocampus.

Adult neurogenesis in the hippocampus: morphology of newborn neuroblasts labeled by DCX (doublecortin) immunocytochemistry.

Neuroplasticity, also known as brain plasticity, refers to the capacity of the nervous system to adapt in response to experience and to internal or external stimulations by modifying the interactions between nerve cells (changes in the connections called “synapses” or in the activity) or by generating new nerve cells. This phenomenon is not limited to embryonic or post-natal development, but occurs all along the life. As an example, the production of new neurons, a process called neurogenesis, is maintained in adulthood, although being restricted to a limited number of brain regions. Neuroplasticity has been notably involved in learning and memory processes. It also occurs under pathological conditions and can either represent compensatory mechanisms counteracting the deficits triggered by neuronal dysfunction or death, or, on the contrary, contribute to or even exacerbate the deficits.

Lydia's lab study Parkison's disease and dopaminergic neurons

Progressive loss of dopamine neurons in the substantia nigra pars compacta (SNc ; delineated by dotted lines) after dysfunction of excitatory amino acid transporters

Parkinson’s disease is a neurodegenerative disorder with high prevalence (second after Alzheimer’s disease), characterized by severe motor symptoms. These symptoms are resulting from the death of a population of neurons located in a deep brain region called locus niger (or “substantia nigra”) using dopamine as a neurotransmitter. Dopamine deficiency triggers dysfunction in the structures innervated by these neurons, in particular the basal ganglia, a set of structures notably involved in motor learning and movement control. Parkinson’s disease is more common in the elderly, with most cases occurring after the age of 60. The degenerative process is associated with adaptive changes in neuronal networks, including a compensatory overactivity of remaining dopamine neurons and functional or structural remodelling in other neuronal systems. The treatments at long term can also trigger adaptive phenomena underlying the maintenance of their beneficial effects or, on the contrary, the appearance of side effects. Characterizing neuroplasticity in Parkinson’s disease and in response to the current treatments might provide the bases for the development of novel therapeutic strategies.

FOR SPECIALISTS

The team combines multilevel expertise and skills to study cellular interactions and neuroplasticity in the adult brain, in particular in the context of basal ganglia-related pathologies, using rodent models.

Ongoing projects are centered on the pathophysiology and treatment of Parkinson’s disease (PD) and the role of glutamatergic systems, with 4 research axes:

1. The anatomofunctional organization of the basal ganglia network and its remodeling in response to dopamine depletion in PD.

2. The cellular/molecular bases of the beneficial or side-effects of the current treatments for PD, i.e. deep brain stimulation of the subthalamic nucleus and L-DOPA treatment, and their interactions. Particular interest is given to activity-driven plasticity by deep brain stimulation at long-term (we own a patented microstimulator allowing chronic stimulation in behaving rat), in possible relationship with motor and non-motor PD symptoms.

3. The research and preclinical evaluation of new therapeutic strategies (novel anatomical targets for DBS and new pharmacological options targeting glutamate systems, such as metabotropic glutamate receptors).

4. The cell death mechanisms linked to dysfunction of glutamate transporters, with the hypothesis that they might contribute to the progression of PD’s neuropathological processes.

Lydia's lab perfom electrophysiology experiment to study neurodegenerescence and cell therapy in mus musculus

Optogenetic control of the activity of striatal cholinergic neurons : in vivo electrophysiological recording illustrating the inhibition of these interneurons by photostimulation of halorhodopsine.

Our approach combines the use or development of relevant experimental models in rodents (chronic deep brain stimulation, genetic model of cell specific ablation, optogenetic modulation of neuronal activity) with a variety of analytic tools including functional anatomy, electrophysiology (in vitro and in vivo), neurochemistry and molecular/cellular  biology.


Selected publications

PUBLICATION

TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.

Caubit X, Gubellini P, Andrieux J, Roubertoux PL, Metwaly M1, Jacq B, Fatmi A, Had-Aissouni L, Kwan KY, Salin P, Carlier M, Liedén A, Rudd E, Shinawi M, Vincent-Delorme C, Cuisset JM, Lemaitre MP10, Abderrehamane F, Duban B, Lemaitre JF, Woolf AS, Bockenhauer D, Severac D, Dubois E, Zhu Y, Sestan N, Garratt AN, Kerkerian-Le Goff L, Fasano L.
Nat Genet. 2016 Sep 26. PMID: 27668656

PUBLICATION

Involvement of Striatal Cholinergic Interneurons and M1 and M4 Muscarinic Receptors in Motor Symptoms of Parkinson's Disease.

Ztaou S, Maurice N, Camon J, Guiraudie-Capraz G, Kerkerian-Le Goff L, Beurrier C, Liberge M, Amalric M.
J Neurosci. 2016 Aug 31;36(35):9161-72. PMID: 27581457

PUBLICATION

LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain.

Tiveron MC, Beurrier C, Céni C, Andriambao N, Combes A, Koehl M, Maurice N, Gatti E, Abrous DN, Kerkerian-Le Goff L, Pierre P, Cremer H.
PLoS One. 2016 Jun 7;11(6):e0157052. PMID: 27272053

PUBLICATION

Metabolic, synaptic and behavioral impact of 5-week chronic deep brain stimulation in hemiparkinsonian rats.

Chassain C, Melon C, Salin P, Vitale F, Couraud S, Durif F, Kerkerian-Le Goff L, Gubellini P.
J Neurochem. 2016 Mar;136(5):1004-16. PMID: 26576509

PUBLICATION

Bee Venom Alleviates Motor Deficits and Modulates the Transfer of Cortical Information through the Basal Ganglia in Rat Models of Parkinson's Disease.

Maurice N, Deltheil T, Melon C, Degos B, Mourre C, Amalric M, Kerkerian-Le Goff L.
PLoS One. 2015 Nov 16;10(11):e0142838. PMID: 26571268

PUBLICATION

Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

Nicolas Maurice, Martine Liberge, Florence Jaouen, Samira Ztaou, Marwa Hanini, Jeremy Camon, Karl Deisseroth, Marianne Amalric, Lydia Kerkerian-Le Goff, Corinne Beurrier
Cell Rep. 2015 Oct 27;13(4):657-66. PMID: 26489458

PUBLICATION

Differential organization of cortical inputs to striatal projection neurons of the matrix compartment in rats.

Deng Y, Lanciego J, Goff LK, Coulon P, Salin P, Kachidian P, Lei W, Del Mar N, Reiner A.
Front Syst Neurosci. 2015 Apr 14;9:51. PMID: 25926776

PUBLICATION

Progressive brain metabolic changes under deep brain stimulation of subthalamic nucleus in parkinsonian rats.

Melon C, Chassain C, Bielicki G, Renou JP, Kerkerian-Le Goff L, Salin P, Durif F.
J Neurochem. 2015 Mar;132(6):703-12. PMID: 25533782

PUBLICATION

Reducing Glypican-4 in ES Cells Improves Recovery in a Rat Model of Parkinson's Disease by Increasing the Production of Dopaminergic Neurons and Decreasing Teratoma Formation.

Fico A, de Chevigny A, Melon C, Bohic M, Kerkerian-Le Goff L, Maina F, Dono R, Cremer H.
J Neurosci. 2014 Jun 11;34(24):8318-23. PMID: 24920634

PUBLICATION

Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress.

Gouix E, Buisson A, Nieoullon A, Kerkerian-Le Goff L, Tauskela JS, Blondeau N, Had-Aissouni L.
Pharmacol Res. 2014 Jun 11;87C:8-17. PMID:24928737

PUBLICATION

Cellular and Behavioral Outcomes of Dorsal Striatonigral Neuron Ablation: New Insights into Striatal Functions.

Révy D, Jaouen F, Salin P, Melon C, Chabbert D, Tafi E, Concetta L, Langa F, Amalric M, Kerkerian-Le Goff L, Marie H, Beurrier C.
Neuropsychopharmacology. 2014 Jun 6. PMID:24903652

PUBLICATION

Distinct effects of mGlu4 receptor positive allosteric modulators at corticostriatal vs. striatopallidal synapses may differentially contribute to their antiparkinsonian action.

Gubellini P, Melon C, Dale E, Doller D, Kerkerian-Le Goff L.
Neuropharmacology. 2014 Oct;85:166-77. PMID:24866785

PUBLICATION

Progressive Parkinsonism by acute dysfunction of excitatory amino acid transporters in the rat

Assous M, Had-Aissouni L, Gubellini P, Melon C, Nafia I, Salin P, Kerkerian-Le-Goff L, Kachidian P
Neurobiol Dis. 2014 May;65:69-81. PMID:24480091

PUBLICATION

Striatal molecular signature of subchronic subthalamic nucleus high frequency stimulation in parkinsonian rat.

Lortet S, Lacombe E, Boulanger N, Rihet P, Nguyen C, Goff LK, Salin P.
PLoS One. 2013 Apr 4;8(4):e60447 PMID: 23593219

PUBLICATION

Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia.

Bennouar KE, Uberti MA, Melon C, Bacolod MD, Jimenez HN, Cajina M, Kerkerian-Le Goff L, Doller D, Gubellini P.
Neuropharmacology. 2013 Mar;66:158-69. PMID: 22491024

PUBLICATION

The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

Jean A, Laurent L, Bockaert J, Charnay Y, Dusticier N, Nieoullon A, Barrot M, Neve R, Compan V.
Transl Psychiatry. 2012 Dec 11;2:e203. PMID: 23233022

PUBLICATION

The nucleus accumbens 5-HTR₄-CART pathway ties anorexia to hyperactivity.

Jean A, Laurent L, Bockaert J, Charnay Y, Dusticier N, Nieoullon A, Barrot M, Neve R, Compan V.
Transl Psychiatry. 2012 Dec 11;2:e203. PMID: 23233022

PUBLICATION

Portable microstimulator for chronic deep brain stimulation in freely moving rats.

Forni C, Mainard O, Melon C, Goguenheim D, Kerkerian-Le Goff L, Salin P.
J Neurosci Methods. 2012 Jul 30;209(1):50-7. PMID: 22659685

PUBLICATION

Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity.

Lopez S, Jouve L, Turle-Lorenzo N, Kerkerian-Legoff L, Salin P, Amalric M.
Neurobiol Dis. 2012 Apr;46(1):69-77. PMID: 22245662

PUBLICATION

High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease.

Khaindrava V, Salin P, Melon C, Ugrumov M, Kerkerian-Le-Goff L, Daszuta A.
Neurobiol Dis. 2011 Jun;42(3):284-91. PMID: 21296669

PUBLICATION

The added value of rabies virus as a retrograde tracer when combined with dual anterograde tract-tracing.

López IP, Salin P, Kachidian P, Barroso-Chinea P, Rico AJ, Gómez-Bautista V, Conte-Perales L, Coulon P, Goff LK, Lanciego JL.
J Neurosci Methods. 2010 Dec 15;194(1):21-7. PMID: 20096304

PUBLICATION

Deep brain stimulation mechanisms: beyond the concept of local functional inhibition.

Deniau JM, Degos B, Bosch C, Maurice N.
Eur J Neurosci. 2010 Oct;32(7):1080-91. PMID: 21039947

PUBLICATION

Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-D-aspartate receptors.

Quintana A, Melon C, Kerkerian-Le Goff L, Salin P, Savasta M, Sgambato-Faure V.
Eur J Neurosci. 2010 Aug;32(3):423-34. PMID: 20673310

PUBLICATION

Deep brain stimulation of the center median-parafascicular complex of the thalamus has efficient anti-parkinsonian action associated with widespread cellular responses in the basal ganglia network in a rat model of Parkinson's disease.

Jouve L, Salin P, Melon C, Kerkerian-Le Goff L.
J Neurosci. 2010 Jul 21;30(29):9919-28. PMID: 20660274

PUBLICATION

[Acetylcholinesterase inhibitors in Alzheimer's disease: further comments on their mechanisms of action and therapeutic consequences].

Nieoullon A.
Psychol Neuropsychiatr Vieil. 2010 Jun;8(2):123-31. [Article in French] PMID: 20525543

PUBLICATION

Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.

Cornille E, Abou-Hamdan M, Khrestchatisky M, Nieoullon A, de Reggi M, Gharib B.
BMC Neurosci. 2010 Apr 23;11:51 PMID: 20416081

PUBLICATION

Ciliary neurotrophic factor protects striatal neurons against excitotoxicity by enhancing glial glutamate uptake.

Beurrier C, Faideau M, Bennouar KE, Escartin C, Kerkerian-Le Goff L, Bonvento G, Gubellini P.
PLoS One. 2010 Jan 1;5(1):e8550. PMID: 20062544

PUBLICATION

Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases.

Gubellini P, Picconi B, Di Filippo M, Calabresi P.
Biochim Biophys Acta. 2010 Jan;1802(1):151-61. PMID: 1968356

PUBLICATION

Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease.

Baunez C, Gubellini P.
Prog Brain Res. 2010;183:235-58. PMID: 20696323

PUBLICATION

Rationale for targeting the thalamic centre-median parafascicular complex in the surgical treatment of Parkinson's disease.

Goff LK, Jouve L, Melon C, Salin P.
Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S167-70. PMID: 20082982

PUBLICATION

Cocaine-induced stereotypy is linked to an imbalance between the medial prefrontal and sensorimotor circuits of the basal ganglia.

Aliane V, Pérez S, Nieoullon A, Deniau JM, Kemel ML.
Eur J Neurosci. 2009 Oct;30(7):1269-79. PMID: 19769590

PUBLICATION

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

Beurrier C, Lopez S, Révy D, Selvam C, Goudet C, Lhérondel M, Gubellini P, Kerkerian-LeGoff L, Acher F, Pin JP, Amalric M.
FASEB J. 2009 Oct;23(10):3619-28. PMID: 19525404

PUBLICATION

Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus.

Soumier A, Banasr M, Lortet S, Masmejean F, Bernard N, Kerkerian-Le-Goff L, Gabriel C, Millan MJ, Mocaer E, Daszuta A.
Neuropsychopharmacology. 2009 Oct;34(11):2390-403. PMID: 19571795

PUBLICATION

Different functional basal ganglia subcircuits associated with anti-akinetic and dyskinesiogenic effects of antiparkinsonian therapies.

Lacombe E, Khaindrava V, Melon C, Oueslati A, Kerkerian-Le Goff L, Salin P.
Neurobiol Dis. 2009 Oct;36(1):116-25. PMID: 19615446

PUBLICATION

Deep brain stimulation in neurological diseases and experimental models: from molecule to complex behavior.

Gubellini P, Salin P, Kerkerian-Le Goff L, Baunez C.
Prog Neurobiol. 2009 Sep;89(1):79-123. PMID: 19559747

PUBLICATION

Changes to interneuron-driven striatal microcircuits in a rat model of Parkinson's disease.

Salin P, López IP, Kachidian P, Barroso-Chinea P, Rico AJ, Gómez-Bautista V, Coulon P, Kerkerian-Le Goff L, Lanciego JL.
Neurobiol Dis. 2009 Jun;34(3):545-52. PMID: 19341798

PUBLICATION

Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment.

Cuomo D, Martella G, Barabino E, Platania P, Vita D, Madeo G, Selvam C, Goudet C, Oueslati N, Pin JP, Acher F, Pisani A, Beurrier C, Melon C, Kerkerian-Le Goff L, Gubellini P.
J Neurochem. 2009 May;109(4):1096-105. PMID: 19519781

PUBLICATION

Role of glutamate transporters in corticostriatal synaptic transmission.

Beurrier C, Bonvento G, Kerkerian-Le Goff L, Gubellini P.
Neuroscience. 2009 Feb 18;158(4):1608-15. PMID: 19063944

PUBLICATION

Impact of surgery targeting the caudal intralaminar thalamic nuclei on the pathophysiological functioning of basal ganglia in a rat model of Parkinson's disease.

Kerkerian-Le Goff L, Bacci JJ, Jouve L, Melon C, Salin P.
Brain Res Bull. 2009 Feb 16;78(2-3):80-4. PMID: 18790021

PUBLICATION

Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine*.

Nieoullon A, Bentué-Ferrer D, Bordet R, Tsolaki M, Förstl H.
Curr Med Res Opin. 2008 Dec;24(12):3357-67. PMID: 19032118

PUBLICATION

High-resolution neuroanatomical tract-tracing for the analysis of striatal microcircuits.

Salin P, Castle M, Kachidian P, Barroso-Chinea P, López IP, Rico AJ, Kerkerian-Le Goff L, Coulon P, Lanciego JL.
Brain Res. 2008 Jul 24;1221:49-58. PMID: 18561898

PUBLICATION

Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: evidence for different regulatory pathways associated with neuronal maturation.

Lortet S, Canolle B, Masmejean F, Nieoullon A.
Neurochem Int. 2008 Jun;52(7):1373-82. PMID: 18400334

PUBLICATION

Preferential vulnerability of mesencephalic dopamine neurons to glutamate transporter dysfunction.

Nafia I, Re DB, Masmejean F, Melon C, Kachidian P, Kerkerian-Le Goff L, Nieoullon A, Had-Aissouni L.
J Neurochem. 2008 Apr;105(2):484-96. PMID: 18042178

PUBLICATION

Na(v)1.7 and Na(v)1.3 are the only tetrodotoxin-sensitive sodium channels expressed by the adult guinea pig enteric nervous system.

Sage D, Salin P, Alcaraz G, Castets F, Giraud P, Crest M, Mazet B, Clerc N.
J Comp Neurol. 2007 Oct 1;504(4):363-78. PMID: 17663442

PUBLICATION

High-frequency stimulation of the subthalamic nucleus potentiates L-DOPA-induced neurochemical changes in the striatum in a rat model of Parkinson's disease.

Oueslati A, Sgambato-Faure V, Melon C, Kachidian P, Gubellini P, Amri M,Kerkerian-Le Goff L, Salin P.
J Neurosci. 2007 Feb 28;27(9):2377-86. PMID: 17329435

PUBLICATION

Deficits of glutamate transmission in the striatum of experimental hemiballism.

Centonze D, Rossi S, Gubellini P, De Chiara V, Tscherter A, Prosperetti C, Picconi B, Bernardi G, Calabresi P, Baunez C.
Neuroscience. 2006 Nov 17;143(1):213-21. PMID: 16938405

PUBLICATION

Chronic high-frequency stimulation of the subthalamic nucleus and L-DOPA treatment in experimental parkinsonism: effects on motor behaviour and striatal glutamate transmission.

Gubellini P, Eusebio A, Oueslati A, Melon C, Kerkerian-Le Goff L, Salin P.
Eur J Neurosci. 2006 Sep;24(6):1802-14. PMID: 17004943

PUBLICATION

The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S.
J Neurochem. 2006 Aug;98(4):1007-18. PMID: 16800850

PUBLICATION

Glutamate leakage from a compartmentalized intracellular metabolic pool and activation of the lipoxygenase pathway mediate oxidative astrocyte death by reversed glutamate transport.

Re DB, Nafia I, Melon C, Shimamoto K, Kerkerian-Le Goff L, Had-Aissouni L.
Glia. 2006 Jul;54(1):47-57. PMID: 16673373

PUBLICATION

Ciliary neurotrophic factor activates astrocytes, redistributes their glutamate transporters GLAST and GLT-1 to raft microdomains, and improves glutamate handling in vivo.

Escartin C, Brouillet E, Gubellini P, Trioulier Y, Jacquard C, Smadja C, Knott GW,Kerkerian-Le Goff L, Déglon N, Hantraye P, Bonvento G.
J Neurosci. 2006 May 31;26(22):5978-89. PMID: 16738240

PUBLICATION

Transient hippocampal down-regulation of Kv1.1 subunit mRNA during associative learning in rats.

Kourrich S, Manrique C, Salin P, Mourre C.
Learn Mem. 2005 Sep-Oct;12(5):511-9. PMID: 16204203

PUBLICATION

Enhanced delivery of gamma-secretase inhibitor DAPT into the brain via an ascorbic acid mediated strategy.

Quéléver G, Kachidian P, Melon C, Garino C, Laras Y, Pietrancosta N, Sheha M, Louis Kraus J.
Org Biomol Chem. 2005 Jul 7;3(13):2450-7. PMID: 15976862

PUBLICATION

Glial soluble factors regulate the activity and expression of the neuronal glutamate transporter EAAC1: implication of cholesterol.

Canolle B, Masmejean F, Melon C, Nieoullon A, Pisano P, Lortet S.
J Neurochem. 2004 Mar;88(6):1521-32. PMID: 15009653

PUBLICATION

Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats.

Breysse N, Amalric M, Salin P.
J Neurosci. 2003 Sep 10;23(23):8302-9. PMID: 12967992

INPI n° 2942412 : Microstimulateur cerebral d’accessibilité aisée et méthode d’installation d’un tel microstimulateur (co-inventors: P. Salin, C. Forni, O. Mainard, C. Melon, E. Richard, and D. Goguenheim) CNRS Patent.

Interactions

IBDM
NATIONAL
  • F. Acher, UMR 8601 CNRS, Paris
  • M. Amalric, LNC, UMR 7291 CNRS/Aix-Marseille Univ
  • G. Bonvento, CEA, MIRCen et CNRS, URA2210 (I2BM)
  • P. Coulon, UMR 7289 CNRS, Marseille
  • F. Durif, Université d’Auvergne, EA 3845
  • D. Goguenheim, ISEN, Toulon
  • H. Marie, IPMC, UMR7275 CNRS/Université Nice Sophia Antipolis
  • C. Nguyen, INSERM U928, TAGC, Marseille
  • J.P. Pin, IGF, CNRS UMR 5203, Montpellier
  • M. Savasta, GIN, Inserm U 836 – UJF – CEA – CHU, Grenoble
INTERNATIONAL
  • K. Deisseroth, Stanford University, California, USA
  • J.L. Lanciego, CIMA, University of Navarra, Pamplona, Spain
  • A. Pisani, University of Rome “Tor Vergata”, Italy
  • A. Richter, Inst Pharmacology and Toxicology, Faculty of Veterinary Medicine, Berlin
  • D. Doller, Lundbeck Res Inc, USA

Funding

Lydia Kerkerian - Le Goff is funded by ANR for her works on Parkinson's disease

Lydia Kerkerian - Le Goff is funded by FRC for her works on neuroplasticity and cell therapy

Lydia Kerkerian - Le Goff is funded by Fondation de France for her works on dopaminergic neurons

Lydia Kerkerian - Le Goff is funded by France Parkison for her works on Parkinson's disease

Lydia Kerkerian - Le Goff is funded by Lundbeck for her works on dopaminergic neurons

Members more

Corinne Beurrier Emilie Dinh Paolo Gubellini Philippe Kachidian Jean-pierre Kessler Gwenaëlle Laverne Sylviane Lortet Nicolas Maurice Christophe Melon André Nieoullon   Thomas Rival Pascal Salin
Lydia Kerkerian - Le Goff
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Lydia Kerkerian - Le Goff

Researcher

Corinne Beurrier
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Corinne Beurrier

Researcher

Emilie Dinh
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Emilie Dinh

PhD student

Paolo Gubellini
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Paolo Gubellini

Researcher

Philippe Kachidian
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Philippe Kachidian

University lecturer

Jean-pierre Kessler
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Jean-pierre Kessler

Researcher

Gwenaëlle Laverne
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Gwenaëlle Laverne

Technical staff

Sylviane Lortet
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Sylviane Lortet

University lecturer

Nicolas Maurice
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Nicolas Maurice

Researcher

Christophe Melon
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Christophe Melon

Technical staff

André Nieoullon
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André Nieoullon

Emeritat

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Jonathan Pesce

PhD student

Thomas Rival
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Thomas Rival

University lecturer

Thomas, University lecturer, joined the team on September 2007. In addition to his teaching responsibilities at the Bachelor and Master levels, Thomas has recently decided to use the power of Drosophila genetic to decipher the molecular mechanisms that control mitochondria dynamics in vivo. He has developed tools that allow him to visualize mitochondria fusion and fission events in vivo and to identify the proteins that regulate this process.

Pascal Salin
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Pascal Salin

Researcher

Overview

Model organisms
Biological process studied
  • Cellular Interactions, neurodegeneration and neuroplasticity
Biological techniques
  • Behavioral tests
  • Cellular/molecular biology
  • Electrophysiology (in vitro and in vivo)
  • Single cell RT-PCR
  • In vivo microdialysis
  • Neuropharmacology
  • Optogenetics
  • Primary cell cultures
  • Quantitative in situ hybridization
  • Quantitative immunocytochemistry
  • Stereotactic surgery
  • Tract-tracing
  • Medical applications

Medical application

  • Basal ganglia-related pathologies (Parkinson’s disease, Huntington’s disease…)