Toll receptors and GPCR signaling were known to control myosin-II activation and planar polarity during axis extension in early Drosophila embryos but whether and how they cooperated in this process was unknown. In this work, Jules Lavalou, Qiyan Mao and colleagues from Thomas Lecuit’s team report that Toll-8 controls myosin-II planar polarity in Drosophila embryos and wing discs via a physical interaction with the GPCR Cirl/latrophilin. They show that Toll-8 expression boundaries generate a Cirl interfacial asymmetry and propose that it is a potential signal leading to myosin-II polarization.


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