Agenda

• Monday, 15 November 2021 13:30

  External Seminar

  Laurent Blanchoin

  CEA, Grenoble

  • Invitation: A. Michelot

• Thursday, 18 November 2021 12:30

  Internal Seminar

  Random Illumination Microscopy for Biology

  Simon Labouesse

  • Lecuit team - Tissue Architecture and Plasticity

    Amphi 12

• Thursday, 25 November 2021 12:30

  Internal Seminar

  Striatal cholinergic interneurons and stereotyped behaviors in Tshz3 deletion-linked autism spectrum disorder

  Jordan Molitor

  • Kerkerian – Le Goff team - Cellular interactions, neurodegeneration and neuroplasticity / Fasano team - Transcriptional regulatory networks in development and diseases/a>

    Amphi 12

• Friday, 26 November 2021 11:30

  External Seminar

  The axonal cytoskeleton at the nanoscale

  Christophe Leterrier

  Aix Marseille Université, CNRS, INP UMR7051, NeuroCyto, Marseille, France

  • Invitation: H. Cremer
  • Hybrid seminar: 40 person in Amphi12 (with registration), the other on Zoom
    Abstract
    The intricate morphology and molecular identity of axons is maintained for decades, but also continuously adapts to changes in the environment and activity of neurons. Axons fulfill these paradoxical demands thanks to a unique cytoskeletal organization that ensures the coordinated transport, anchoring and mobility of axonal components. In our lab, we use super-resolution microscopy to map the nanoscale architecture actin-based structures within the axon. In the axon initial segment, a key compartment for the maintenance of neuronal polarity, we resolved a highly organized assembly encompassing the periodic actin/spectrin scaffold and its partners: ankyrin, myosin. We have also visualized new actin structures along the axon shaft: rings, hotspots and trails, and are now exploring their molecular organization and functions as well as the role of actin at presynapses. For this, we develop a combination of versatile labeling, correlative live-cell/super-resolution/electron microscopy and quantitative, deep-learning based analysis that allow for high-content, nanoscale interrogation of the axonal architecture.