Frank SCHNORRER, head of the « Muscle Dynamics » team at the Institute of Developmental Biology of Marseille Aix-Marseille University, has been awarded a prestigious Human Frontier Science Program (HSFP) Research Grant.
HFSP Research Grants are awarded for collaborative projects. Frank SCHNORRER together with his collaborators, Olivier POURQUIE (Harvard Medical School, Boston, US) and Benjamin FRIEDRICH (Technical University, Dresden, Germany) will investigate « Muscle building: dissecting tension-driven myofibrillogenesis in vitro, in vivo and in silico ». The teams aim to uncover mechanisms how mechanical forces regulate sarcomere assembly in Drosophila muscle in vivo (F. SCHNORRER) and in human skeletal muscle in vitro (O.POURQUIE). Importantly, the experimental approaches are complemented by a mathematical model of myofibrillogenesis, which in turn will be able to make predictions how tension can regulate self-organisation of myofibrils (B. FRIEDRICH).
The application was ranked well within 23 projects chosen for funding from 63 full applications received (from an initial total of 612 letters of intent). The project has been awarded $350,000 per year for a period of three years.
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