The National Research Agency has published the list of winning projects in the Collaborative Research category (PRC), selected as part of its generic call for projects 2018 (appel à projets générique 2018).

The projects of 5 IBDM teams have been selected.

Only 14.1% of submitted projects were selected for funding by the AAPG in 2018. With these 5 winners, the IBDM is at the top of the research institutes funded by the ANR this year.

IBDM-ANR

Bianca HABERMANN- MITO-DYNAMICS: Systematic functional analysis of mitochondrial dynamics in healthy young, aged and sarcopenic muscle.

In the MITO-DYNAMICS project, a consortium of 4 research teams [Bianca Habermann (IBDM) Frank Schnorrer (IBDM), Alice Carrier (CRCM) and Benoit Giannesini (CRMBM)]

is going to characterize mitochondrial changes in the ageing and sarcopenic muscle in mouse models and during the life-time of a fly under different exercise conditions by integrating data from transcriptomics, proteomics, metabolomics, MRI measurements, as well as imaging techniques.

 

Cédric MAURANGE- MASTERMOD: Mode of action of a “stem cell self-renewing module”specific to early development.

Stem cells during early development share many properties with cancer cells. This MASTERMOD project aims at understanding how a transcription factor and an RNA-binding protein cooperate to establish a gene expression profile that promotes a default proliferative state found during both early development and tumorigenesis.

 

Julien ROYET- PEPTIMET: How does microbiota-born peptidoglycan affect host homeostasis?

Taking advantage of the power of Drosophila genetics the Royet’s laboratory studies the molecular mechanisms by which gut microbiota interfere with its host physiology and behavior. The PEPTIMET project is aimed at revealing how one gut-born universal bacterial compound, called peptidoglycan, reaches the fly brain and modifies the physiology of neurons and glial cells.

 

Benjamin PRUDHOMME- CHEMOSUZ: Chemogenetic characterization of the egg-laying behaviour of the fruit pest species Drosophila suzukii.

The CHEMOSUZ project aims at identifying the fruit odours and the olfactory receptors that control the egg-laying behaviour of the agricultural pest Drosophila suzukii.

 

Robert KELLY- HEARTBOX: Investigation of the mechanisms patterning epithelial cardiac progenitor cells in the early mouse embryo.

The HEARTBOX project will characterize the genetic, molecular and cellular mechanisms driving progenitor cell patterning in early cardiac morphogenesis. By focussing on the roles of two T-box transcription factors implicated in 22q11.2 deletion syndrome and Holt-Oram syndrome in the emergence of distinct progenitor cell populations our project aims to provide insights into the origins of common forms of congenital heart defects.