Agenda

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septembre 2021

  • Friday, 10 September 2021 10:30

    External Seminar

    Muscle-resident fibro-adipogenic progenitors are essential structural and talkative cells in health, regeneration, and disease

    Osvaldo Contreras

    Victor Chang Cardiac Research Institute, Sydney, Australia

    • F. Helmbacher
    • THIS SEMINAR WILL BE RESCHEDULED

  • Friday, 17 September 2021 14:00

    External Seminar

    A new pharmacological approach for hair cell regeneration in the adult mouse utricle

    Hanae Lahlou

    Harvad University, Cambridge, USA

    • NeuroSchool - Rosanna Dono
    • Zoominar at 2pm The inner ear is a highly specialized sensory organ containing auditory and vestibular hair cells, mechanoreceptors for hearing and balance. Loss of auditory hair cells is clinically irreversible. While vestibular hair cells can regenerate spontaneously in response to damage, their regeneration potential appears limited and declines from a high point in the first postnatal weeks through adulthood. We sought to develop a pharmacological treatment to enhance vestibular hair cell regeneration in the damaged adult utricle. We used adult Pou4f3DTR mice for targeted ablation of hair cells. After in vivo administration of diphtheria toxin, damaged adult utricles were treated in vitro with a combination of a glycogen synthase kinase inhibitor and a histone deacetylase inhibitor, a combination shown previously to stimulate production of new hair cells in the cochlea. Hair cell regeneration was significantly increased relative to the spontaneous regeneration observed in utricles with damage alone. Lineage tracing of supporting cells showed differentiation into both type I and type II vestibular hair cells. We confirmed these results in vivo, where we injected the same drug combination into damaged adult mouse ears via the semi-circular canal. Ultimately, our work provides new knowledge of the molecular mechanisms required for vestibular hair cell differentiation and may pave the way toward the development of new therapeutic strategies to produce hair cells and restore vestibular function in humans.

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