Andrea Pasini, in the Le Bivic’s team, has recently been awarded a grant from the CNRS Programme ‘Diversity of Biological Mechanisms’, to study the epithelial plasticity of Trichoplax.

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The Lenne team published in Elife: using gastruloids –3D aggregates of mouse embryonic stem cells- they study at cellular resolution the specification of the endoderm.

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These findings provide novel insights into the implication of the corticostriatal circuitry in ASD by revealing an unexpected neuronal dichotomy in the biological background of the two core behavioral domains of this disorder.

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The Helmbacher team identified the Fat1 Cadherin as a novel regulator of retinal vascular integrity, and investigated the underlying mechanisms.

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Our work demonstrates that by activating the NF-kB pathway, cell wall peptidoglycan produced by these same bacteria, counteracts SREBP activation in adipocytes in a cell-autonomous manner.

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Our results allow us to propose a simple and efficient model of how life could generate new functions through the use of new actin isoforms.

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Data published in Hum Mol Genet. confirm that Tshz3 heterozygous mice constitute a model that replicates many of the clinical problems reported in patients with TSHZ3 heterozygous conditions.

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The selected candidates will receive support to establish a group in a fully renovated building, have access to cutting-edge scientific core facilities, and will be assisted in obtaining a tenured position, and in securing extramural funding.

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Our findings provide mechanistic insight into the mechanism by which TAFA4 reverses injury-induced mechanical hypersensitivity, by restoring normal spinal neuron activity, and highlight the considerable potential of TAFA4 as a treatment for injury-induced mechanical pain.

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Through an international collaboration, using breast cancer as a biological paradigm, Flavio Maina Team publishes a work in the Theranostics journal exemplifying how specificity in targeting cell cycle regulators is essential for combinatorial cancer therapies.

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