By combining optogenetics with behavioral and electrophysiological approaches in mice, Maurice et al. provide the first direct evidence for a causal role of striatal cholinergic interneurons in parkinsonian symptomatology and identify underlying neural substrates in the basal ganglia network.

Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

Nicolas Maurice, Martine Liberge, Florence Jaouen, Samira Ztaou, Marwa Hanini, Jeremy Camon, Karl Deisseroth, Marianne Amalric, Lydia Kerkerian-Le Goff, Corinne Beurrier

Maurice et al., 2015, Cell Rep 13 (4), 657–666.

Contact: Corinne Beurrier corinne.beurrier@univ-amu.fr