In patients with Multiple Sclerosis, spontaneous repair mechanisms can be observe, allowing the synthesis of a new functional myelin sheath. Unfortunately, these regeneration processes are insufficient to allow functional recovery. In this context it is important to better understand these mechanisms and to identify strategies to promote them. Pascale Durbec’ team showed, in an experimental model of demyelination in mice, that neuroblasts from adult brain stem cells can participate in this repair. The team’s shows that forced expression of two transcription factors, Olig2 and Sox10, is sufficient to induce reprogramming of neuroblasts into oligodendrocytes and promote the repair process in animals. These studies are a first step towards the development of therapies for patients with multiple sclerosis.
To know more :
El Waly B, Cayre M, Durbec P. Stem Cell Reports. 2018 May 8;10(5):1492-1504.
doi: 10.1016/j.stemcr.2018.02.015. PMID: 29606615