In a collaborative study published in Development, the teams of Vincent Bertrand and Pierre-François Lenne analyze the role played by Wnt ligands in the divisions that generate neurons during nervous system development. Using time-controlled perturbations and quantitative imaging, they established that Wnt ligands regulate the shape of neuronal progenitors and their asymmetric divisions in an instructive manner. Wnt ligands act via a Frizzled receptor and an APC protein that is asymmetrically localized at the cortex of progenitors and unequally inherited by the daughter cells.
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Development 2020 147: dev183186 doi: 10.1242/dev.183186 Published 6 April 2020
Shilpa Kaur, Pauline Mélénec, Sabrina Murgan, Guillaume Bordet, Pierre Recouvreux, Pierre-François Lenne, Vincent Bertrand